Plx-4032 (RG7024)
Vemurafenib
CAS: 1029872-54-5;918504-65-1
Molecular Formula: C23H18ClF2N3O3S
Plx-4032 (RG7024) - Names and Identifiers
Plx-4032 (RG7024) - Physico-chemical Properties
| Molecular Formula | C23H18ClF2N3O3S |
| Molar Mass | 489.9221264 |
| Density | 1.46 |
| Melting Point | >263oC (dec.) |
| Solubility | Soluble in DMSO (100 mg/mL), and methanol. Insoluble in ethanol, and water |
| Appearance | Solid |
| Color | Off-White |
| Storage Condition | Refrigerator |
| Use | A novel and potent inhibitor of B- RAFV600E with IC50 of 31 nM. |
Plx-4032 (RG7024) - Reference
| Reference Show more | 1. [IF=9.162] Kun Zhao et al."Morusin enhances the antitumor activity of MAPK pathway inhibitors in BRAF-mutant melanoma by inhibiting the feedback activation of STAT3."Eur J Cancer. 2022 Apr;165:58 |
Plx-4032 (RG7024) - Introduction
Vemurafenib (PLX4032, RG7204) is a new and effective B- Raf V600E inhibitor with IC50 of 31 nM.
Last Update：2022-10-16 17:11:36
Plx-4032 (RG7024) - Reference Information
| overview | vilafenib (Vemurafenib), trade name Zelboraf, is a kinase inhibitor developed by Roche (HoffmannLaRoche) company for the treatment of patients with unresectable or metastatic melanoma and BRAFV600E mutations approved by FDA. it was approved by FDA in August 2011 for the treatment of advanced metastatic or unresectable melanoma. |
| Application | Verofenib is a small molecule BRAF kinase inhibitor that can selectively bind to the ATP binding domain of mutant BRAF, thereby inhibiting the activation of the enzyme. The US Food and Drug Administration (FDA) has approved Verofenib for the treatment of malignant melanoma with BRAF gene mutation. |
| preparation | preparation of vilafenib (I): add 250g of toluene and 31.5g (0.10 mol) N-[2] to a 500 ml four-mouth flask connected with stirring, thermometer and reflux condenser tube with water separator, 4-Difluoro-3-(cyanopropionyl) phenyl] n-propyl sulfonamide, 17.0 grams (0.11 moles) of p-chlorophenyl acetaldehyde, 0.5 grams of piperidine, heating, stirring, 83-85 ℃ azeotropic reflux with water Condensation reaction for 5 hours; cooling to 30 ℃, adding 38.0 grams (0.32 moles) of N,N-dimethylformamide dimethanol, stirring at 85-90 ℃ for 6 hours; cooling to 30 ℃, 70.0g of 10wt% ammonia methanol solution was added and stirred at 50~55 ℃ for 4 hours. Decompression distillation recovers methanol and toluene, adds 200 grams of isopropanol to the residue, heats to 80 ℃, cools, recrystallizes, filters, dries to obtain 43.9 kverafenib with 89.6% yield and 99.91% liquid phase purity. |
Last Update：2024-04-09 21:11:58
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Multiple SpecificationsSpot supply
Product Name: PLX4032; RG7204; RO5185426 Visit Supplier Webpage Request for quotationCAS: 918504-65-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Multiple SpecificationsSpot supply
Product Name: Plx-4032 Visit Supplier Webpage Request for quotationCAS: 1029872-54-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Vemurafenib (PLX4032, RG7204) Visit Supplier Webpage Request for quotationCAS: 918504-65-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Vemurafenib (PLX4032, RG7204) Visit Supplier Webpage Request for quotationCAS: 918504-65-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
Plx-4032 (RG7024)
Iodomethane-13C,d3 (Copper Wire Stabilized)
化合物TEPOTINIB HYDROCHLORIDE(1 : X)
GINSENOSIDE RC 人参皂苷RC
(4-(4-甲基噻唑-5-基)苯基)甲胺盐酸盐
5-碘-4-甲氧基-6-甲基嘧啶-2-胺
2-(甲基氨基)吡啶-4-硼酸频哪醇酯
4-(苯基甲基)-1-哌嗪乙酸 2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼
ETHYL 1-(PENT-4-ENYL)PIPERIDINE-3-CARBOXYLATE
E-PERFLUORO(4-METHYLPENT-2-ENOIC ACID)
Iodomethane-13C,d3 (Copper Wire Stabilized)
化合物TEPOTINIB HYDROCHLORIDE(1 : X)
GINSENOSIDE RC 人参皂苷RC
(4-(4-甲基噻唑-5-基)苯基)甲胺盐酸盐
5-碘-4-甲氧基-6-甲基嘧啶-2-胺
2-(甲基氨基)吡啶-4-硼酸频哪醇酯
4-(苯基甲基)-1-哌嗪乙酸 2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼
ETHYL 1-(PENT-4-ENYL)PIPERIDINE-3-CARBOXYLATE
E-PERFLUORO(4-METHYLPENT-2-ENOIC ACID)